Regulation of CRISPR genetic editing

This project aims to investigate the substantive and procedural aspects of regulating genetic editing through CRISPR techniques.

Outputs of the project:

(Last update 1 July 2020)

Below is a collection of resources on the regulation of CRISPR genetic editing, including pieces of legislation and policies, web resources, and academic papers.

Legislation and policies

Committees and agencies

Resources

Academic journals

The CRISPR Journal

Perspectives in Biology and Medicine, Special issue on CRISPR (Winter 2020)

Nature, Adopt a moratorium on heritable genome editing (March 2019)

The Harvard Gazette, Perspectives on gene editing (January 2019)

Nature, First CRISPR babies: six questions that remain, How the genome-edited babies revelation will affect research, Genome-edited baby claim provokes international outcry (November 2018)

The Lancet, Genome editing: science, ethics, and public engagement (August 2017)

Academic papers on regulation of CRISPR

2020

Akpoviri, F., Zainol, Z., & Baharum, S. (2020). Synthetic Biology and Biosafety Governance in the European Union and the United States. IIUM Law Journal28(1), 37-71.

Annas, G. J. (2020). Genome Editing 2020: Ethics and Human Rights in Germline Editing in Humans and Gene Drives in Mosquitoes. American Journal of Law & Medicine46(2-3), 143-165.

Arguedas-Ramírez, G. (2020). Ethics and Global Governance of Human Germline Genome Editing: The Problem of Techno-Scientific Colonialist Paternalism. The CRISPR Journal3(2), 83-88.

van Beers, B. C. (2020). Rewriting the Human Genome, Rewriting Human Rights Law? Human Rights, Human Dignity, and Human Germline Modification in the CRISPR Rra. Journal of Law and the Biosciences. (online 9/6/2020)

Bertka, C. M. (2020). The CRISPR Apple on the Tree of Knowledge Conference Highlights: CRISPR in Science, Ethics, and Religion. Zygon55(2), 444-458.

Doxzen, K., & Halpern, J. (2020). Focusing on Human Rights: a framework for CRISPR germline genome editing ethics and regulation. Perspectives in Biology and Medicine63(1), 44-53.

Firestone, J. (2020). The need for soft law to regulate synthetic biology. Jurimetrics60(2), 139-173.

Garland-Thomson, R. (2020). How We Got to CRISPR: The Dilemma of Being Human. Perspectives in Biology and Medicine63(1), 28-43.

Isa, N. M., Zulkifli, N. A., & Man, S. (2020). Islamic perspectives on CRISPR/Cas9-mediated human germline gene editing: a preliminary discussion. Science and Engineering Ethics26(1), 309-323.

Jiang, L. (2020). Commercialization of the gene-edited crop and morality: challenges from the liberal patent law and the strict GMO law in the EU. New Genetics and Society39(2), 191-218.

Johnston, J. (2020). Shaping the CRISPR Gene-Editing Debate: Questions About Enhancement and Germline Modification. Perspectives in Biology and Medicine63(1), 141-154.

Kleiderman, E., & Stedman, I. N. K. (2019). Human germline genome editing is illegal in Canada, but could it be desirable for some members of the rare disease community?. Journal of community genetics, 1-10.

Martin, P., Morrison, M., Turkmendag, I., Nerlich, B., McMahon, A., de Saille, S., & Bartlett, A. (2020). Genome editing: the dynamics of continuity, convergence, and change in the engineering of life. New Genetics and Society39(2), 219-242.

Nestor, M. W., & Wilson, R. L. (2020). Beyond Mendelian genetics: anticipatory biomedical ethics and policy implications for the use of CRISPR together with gene drive in humans. Journal of Bioethical Inquiry, 1-12.

Padden, C., & Humphries, J. (2020). Who Goes First? deaf people and CRISPR germline editing. Perspectives in Biology and Medicine63(1), 54-65.

Patrick, S. M. (2020). Can We Learn to Incentivize Morality?: A Discussion of Biotechnology on an International Level. Emory Int’l L. Rev.34, 859.

Safaei, M., Mobini, G. R., Abiri, A., & Shojaeian, A. (2020). Synthetic biology in various cellular and molecular fields: applications, limitations, and perspective. Molecular Biology Reports, 1-10.

Shozi, B., & Dhai, A. (2020). A Critical Review of the Ethical and Legal Issues in Human Germline Gene Editing: Considering Human Rights and a Call for an African Perspective. South African Journal of Bioethics and Law13(1), 54-59.

Soni, S. (2020). CRISPR and the Law: A South African Perspective. The CRISPR Journal3(2), 81-82.

Thizy, D., Coche, I., & de Vries, J. (2020). Providing a policy framework for responsible gene drive research: an analysis of the existing governance landscape and priority areas for further research. Wellcome Open Research5(173), 173.

de Wit, M. M. (2020). Democratizing CRISPR? Stories, practices, and politics of science and governance on the agricultural gene editing frontier. Elem Sci Anth8(1).

Wollert, D. (2020). The Fascinating & Controversial New Science of CRISPR. The American Biology Teacher82(5), 279-288.

2019

Alsaigh, T., Nicholson, L., & Topol, E. (2019). What Should Clinicians Do to Engage the Public About Gene Editing?. AMA Journal of Ethics21(12), 1089-1097.

Blasimme, A. (2019). Why Include the Public in Genome Editing Governance Deliberation?. AMA Journal of Ethics21(12), 1065-1070.

Boggio, A., Knoppers, B. M., Almqvist, J., & Romano, C. P. (2019). The human right to science and the regulation of human germline engineering. The CRISPR Journal2(3), 134-142.

Bratlie, S., Halvorsen, K., Myskja, B. K., Mellegård, H., Bjorvatn, C., Frost, P., … & Malnes, R. S. (2019). A novel governance framework for GMO: A tiered, more flexible regulation for GMO s would help to stimulate innovation and public debate. EMBO reports20(5), e47812.

Braun, M., & Meacham, D. (2019). The trust game: CRISPR for human germline editing unsettles scientists and society. EMBO reports20(2), e47583.

Brokowski, C., & Adli, M. (2019). CRISPR ethics: moral considerations for applications of a powerful tool. Journal of molecular biology431(1), 88-101.

Conley, J. M. (2019). Introduction: A Lawyer’s Guide to CRISPR. North Carolina Law Review97(5), 1041.

Cunningham, A. (2018). A Cleaner, CRISPR Constitution: Germline Editing and Fundamental Rights. Wm. & Mary Bill Rts. J.27, 877.

van Eenennaam, A. L., Wells, K. D., & Murray, J. D. (2019). Proposed US regulation of gene-edited food animals is not fit for purpose. npj Science of Food3(1), 1-7.

Feeney, O. (2019). Editing the gene editing debate: Reassessing the normative discussions on emerging genetic technologies. NanoEthics13(3), 233-243.

Greely, H. T. (2019). CRISPR’d babies: human germline genome editing in the ‘He Jiankui affair’. Journal of Law and the Biosciences6(1), 111-183.

Gumer, J. M. (2019). The wisdom of germline editing: an ethical analysis of the use of CRISPR-Cas9 to edit human embryos. The New Bioethics25(2), 137-152.

Halpern, J., O’Hara, S. E., Doxzen, K. W., Witkowsky, L. B., & Owen, A. L. (2019). Societal and Ethical Impacts of Germline Genome Editing: How Can We Secure Human Rights?. The CRISPR journal2(5), 293-298.

Hashmi, F. (2019). Necessity or Vanity: Designer Babies, CRISPR, and the Future of Genetic Modifications. International Journal of Scientific Research and Management7(11).

Jorasch, P. (2020). Will the EU stay out of step with science and the rest of the world on plant breeding innovation?. Plant Cell Reports39(1), 163-167.

Kleiderman, E., & Ogbogu, U. (2019). Realigning gene editing with clinical research ethics: what the “CRISPR Twins” debacle means for Chinese and international research ethics governance. Accountability in research26(4), 257-264.

Knoppers, B. M., & Kleiderman, E. (2019). “CRISPR babies”: What does this mean for science and Canada?. CMAJ191(4), E91-E92.

Lassoued, R., Macall, D. M., Smyth, S. J., Phillips, P. W., & Hesseln, H. (2019). Risk and safety considerations of genome edited crops: Expert opinion. Current Research in Biotechnology1, 11-21.

Martin-Laffon, J., Kuntz, M., & Ricroch, A. E. (2019). Worldwide CRISPR patent landscape shows strong geographical biases. Nature biotechnology37(6), 613-620.

Marcon, A., Master, Z., Ravitsky, V., & Caulfield, T. (2019). CRISPR in the North American popular press. Genetics in Medicine21(10), 2184-2189.

Matthews, K. R., & Iltis, A. S. (2019). Are we ready to genetically modify a human embryo? Or is it too late to ask?. Accountability in research26(4), 265-270.

McConnell, S. C. (2019). An Exclusive Interview With CRISPR. AMA Journal of Ethics21(12), 1079-1088.

Morrison, M., & de Saille, S. (2019). CRISPR in context: towards a socially responsible debate on embryo editing. Palgrave Communications5(1), 1-9.

Muller, M., Schneider, M., Salathé, M., & Vayena, E. (2019). Combining Crowdsourcing and Deep Learning to Assess Public Opinion on CRISPR-Cas9. BioRxiv, 802454.

Peters, T. (2019). Are we closer to free market eugenics? The crispr controversy. Zygon®54(1), 7-13.

Rufo, F., & Ficorilli, A. (2019). From Asilomar to Genome Editing: Research Ethics and Models of Decision. NanoEthics13(3), 223-232.

Scott, C. T., & Selin, C. (2019). What to Expect When Expecting CRISPR Baby Number Four. The American Journal of Bioethics19(3), 7-9.

Sherkow, J. S. (2019). Controlling CRISPR Through Law: Legal Regimes as Precautionary Principles. The CRISPR journal2(5), 299-303.

Taylor, C., & Dewsbury, B. (2019). Barriers to inclusive deliberation and democratic governance of genetic technologies at the science-policy interface. Journal of Science Communication18(3), Y02.

Wasmer, M. S. (2019). Roads forward for European GMO policy–uncertainties in wake of ECJ judgment have to be mitigated by regulatory reform. Frontiers in bioengineering and biotechnology7, 132.

2018

Bartkowski, B., Theesfeld, I., Pirscher, F., & Timaeus, J. (2018). Snipping around for food: economic, ethical and policy implications of CRISPR/Cas genome editing. Geoforum96, 172-180.

Brokowski, C. (2018). Do CRISPR germline ethics statements cut it?. The CRISPR journal1(2), 115-125.

Ceccarelli, L. (2018). CRISPR as agent: a metaphor that rhetorically inhibits the prospects for responsible research. Life sciences, society and policy14(1), 24.

Duensing, N., Sprink, T., Parrott, W. A., Fedorova, M., Lema, M. A., Wolt, J. D., & Bartsch, D. (2018). Novel features and considerations for ERA and regulation of crops produced by genome editing. Frontiers in bioengineering and biotechnology6, 79.

Faunce, T., Ray, A., Gardiner, C., Preiss, T., & Burgio, G. (2018). Regulating RNA Research and CRISPR Gene Drives to Combat Biosecurity Threats. Journal of law and medicine26(1), 208-213.

Feeney, O., Cockbain, J., Morrison, M., Diependaele, L., Van Assche, K., & Sterckx, S. (2018). Patenting foundational technologies: Lessons from CRISPR and other core biotechnologies. The American Journal of Bioethics18(12), 36-48.

Gao, C. (2018). The future of CRISPR technologies in agriculture. Nature Reviews Molecular Cell Biology19(5), 275-276.

Gelinsky, E., & Hilbeck, A. (2018). European Court of Justice ruling regarding new genetic engineering methods scientifically justified: a commentary on the biased reporting about the recent ruling. Environmental Sciences Europe30(1), 52.

Globus, R., & Qimron, U. (2018). A technological and regulatory outlook on CRISPR crop editing. Journal of cellular biochemistry119(2), 1291-1298.

Greene, M., & Master, Z. (2018). Ethical issues of using CRISPR technologies for research on military enhancement. Journal of bioethical inquiry15(3), 327-335.

Guerrini, C. J., Spencer, G. E., & Zettler, P. J. (2018). DIY CRISPR. NCL Rev.97, 1399.

Gutmann, A., & Moreno, J. D. (2018). Keep CRISPR safe: regulating a genetic revolution. Foreign Aff.97, 171.

Guttinger, S. (2018). Trust in science: CRISPR–Cas9 and the ban on human germline editing. Science and engineering ethics24(4), 1077-1096.

Hebert, M. D. (2018). Opening a Can of Genetically-Modified Worms: Funding and Regulating CRISPR Technology. Valparaiso University Law Review52(3), 3.

Howard, H. C., van El, C. G., Forzano, F., Radojkovic, D., Rial-Sebbag, E., de Wert, G., … & Cornel, M. C. (2018). One small edit for humans, one giant edit for humankind? Points and questions to consider for a responsible way forward for gene editing in humans. European Journal of Human Genetics26(1), 1-11.

LaManna, C. M., & Barrangou, R. (2018). Enabling the rise of a CRISPR world. The CRISPR journal1(3), 205-208.

Lovell, K. (2017). CRISPR/Cas-9 Technologies: A Call for a New Form of Tort. San Diego Int’l LJ19, 407.

Medvedieva, M. O., & Blume, Y. B. (2018). Legal regulation of plant genome editing with the CRISPR/Cas9 technology as an example. Cytology and Genetics52(3), 204-212.

Mosby, H. (2018). Biotechnology’s Great Divide: Strengthening the Relationship between Patent Law and Bioethics in the Age of CRISPR-Cas9. Minn. JL Sci. & Tech.19, 565.

Novak, B. J., Maloney, T., & Phelan, R. (2018). Advancing a new toolkit for conservation: from science to policy. The CRISPR journal1(1), 11-15.

Pillay, S., & Thaldar, D. W. (2018). CRISPR: Challenges to South African biotechnology law. South African Journal of Bioethics and Law11(2), 89-92.

Schultz-Bergin, M. (2018). Is CRISPR an ethical game changer?. Journal of Agricultural and Environmental Ethics31(2), 219-238.

Shew, A. M., Nalley, L. L., Snell, H. A., Nayga Jr, R. M., & Dixon, B. L. (2018). CRISPR versus GMOs: Public acceptance and valuation. Global food security19, 71-80.

Smalley, E. (2018). As CRISPR–Cas adoption soars, summit calls for genome editing oversight.

Tomlinson, T. (2018). A crispr future for gene-editing regulation: a proposal for an updated biotechnology regulatory system in an era of human genomic editing. Fordham L. Rev.87, 437.

Warford, B. (2018). Regulating Evolution: Smart Policy for the 21st Century. Ky. LJ107, 315.

Wolt, J. D., & Wolf, C. (2018). Policy and governance perspectives for regulation of genome edited crops in the United States. Frontiers in plant science9, 1606.

Zhang, D., & Lie, R. K. (2018). Ethical issues in human germline gene editing: a perspective from China. Monash Bioethics Review36(1-4), 23-35.

2017

Andoh, C. T. (2017). Genome editing technologies: ethical and regulation challenges for Africa. International Journal of Health Economics and Policy2(2), 30-46.

de Araujo, M. (2017). Editing the genome of human beings: CRISPR-Cas9 and the ethics of genetic enhancement. Journal of Evolution and Technology27, 24-42.

Barnett, S. A. (2016). Regulating Human Germline Modification in Light of CRISPR. U. Rich. L. Rev.51, 553.

Brinegar, K., K. Yetisen, A., Choi, S., Vallillo, E., Ruiz-Esparza, G. U., Prabhakar, A. M., … & Yun, S. H. (2017). The commercialization of genome-editing technologies. Critical reviews in biotechnology37(7), 924-932.

Cribbs, A. P., & Perera, S. M. (2017). Focus: Genome Editing: Science and Bioethics of CRISPR-Cas9 Gene Editing: An Analysis Towards Separating Facts and Fiction. The Yale journal of biology and medicine90(4), 625.

Enriquez, P. (2016). CRISPR GMOs. NCJL & Tech.18, 432.

Esvelt, K., & Millett, P. D. (2017). Genome editing as a national security threat. Revue scientifique et technique (International Office of Epizootics)36(2), 459-465.

Furrow, B. R., & Richards, B. J. (2017). Regulating the New: A Consideration of CRISPR and Approaches to Professional Standards of Practitioners of Chinese Medicine in Australia and Accessing the NDIS. Journal of Bioethical Inquiry14(2), 167-172.

Gabriel, W. (2017). The CRISPR-Cas9 mediated disruption in the ethics of gene therapy: an analysis of contemporary developments.

Ishii, T., & Araki, M. (2017). A future scenario of the global regulatory landscape regarding genome-edited crops. GM crops & food8(1), 44-56.

Kozubek, J. (2017). Crispr-Cas9 is Impossible to Stop. Geo. J. Int’l Aff.18, 112.

de Lecuona, I., Casado, M., Marfany, G., Baroni, M. L., & Escarrabill, M. (2017). Focus: genome editing: gene editing in humans: towards a global and inclusive debate for responsible research. The Yale Journal of Biology and Medicine90(4), 673.

Melillo, T. R. (2017). Gene editing and the rise of designer babies. Vand. J. Transnat’l L.50, 757.

Mulvihill, J. J., Capps, B., Joly, Y., Lysaght, T., Zwart, H. A., & Chadwick, R. (2017). Ethical issues of CRISPR technology and gene editing through the lens of solidarity. British medical bulletin122(1), 17-29.

Ormond, K. E., Mortlock, D. P., Scholes, D. T., Bombard, Y., Brody, L. C., Faucett, W. A., … & Musunuru, K. (2017). Human germline genome editing. The American Journal of Human Genetics101(2), 167-176.

Peck, A. (2017). Re-framing biotechnology regulation. Food and Drug Law Journal72(2), 314-340.

Rai, A. K., & Cook-Deegan, R. (2017). Racing for academic glory and patents: Lessons from CRISPR. Science358(6365), 874-876.

Sherkow, J. S. (2017). Focus: Genome Editing: CRISPR, Patents, and the Public Health. The Yale Journal of Biology and Medicine90(4), 667.

Shinwari, Z. K., Tanveer, F., & Khalil, A. T. (2017). Ethical issues regarding CRISPR mediated genome editing. Curr Issues Mol Biol26, 103-110.

Wang, K. (2017). CRISPR and the future of genome engineering: A bold new world. Intersect: The Stanford Journal of Science, Technology, and Society10(3).

Weisberg, S. M., Badgio, D., & Chatterjee, A. (2017). A CRISPR new world: attitudes in the public toward innovations in human genetic modification. Frontiers in public health5, 117.

2016

Ellison, T. (2016). Why Genetics Is CRISPR Than It Used to Be: Helping the Novice Understand Germ Line Modification and Its Serious Implications. S. Cal. Interdisc. LJ26, 595.

Hrouda, B. E. (2016). Playing God: An Examination of the Legality of CRISPR Germline Editing Technology under the current International Regulatory Scheme and the Universal Declaration on the Human Genome and Human Rights. Ga. J. Int’l & Comp. L.45, 221.

Williams, E. E. (2016). CRISPR: Redefining GMOs-One Edit at a Time. UALR L. Rev.39, 437.